09-P021 Atonal regulates Rfx during chordotonal organ development in the Drosophila

نویسندگان

  • Lina Ma
  • Andrew Jarman
چکیده

base. The anterior cranial base shows an abnormal differentiation of chondrocytes in the mutant, with reduced proliferation and increased terminal differentiation. The main factors responsible to restrict Six2 function to the anterior portion of the cranial base are the tissue-specific transcription of the gene and the presence of compensatory effects from other Six family members, in particular Six1 and Six4. Gain of function experiments indicate that Six2 has a general effect on endochondral bone formation and can affect cartilage development and growth in other body areas. It is likely that Six2 acts by controlling general regulators of chondrocyte differentiation. Our data suggest that Six2 acts to control locally the level of the IGF-axis.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The Gene Regulatory Cascade Linking Proneural Specification with Differentiation in Drosophila Sensory Neurons

In neurogenesis, neural cell fate specification is generally triggered by proneural transcription factors. Whilst the role of proneural factors in fate specification is well studied, the link between neural specification and the cellular pathways that ultimately must be activated to construct specialised neurons is usually obscure. High-resolution temporal profiling of gene expression reveals t...

متن کامل

Transcriptional regulation of atonal during development of the Drosophila peripheral nervous system.

atonal is a proneural gene for the development of Drosophila chordotonal organs and photoreceptor cells. We show here that atonal expression is controlled by modular enhancer elements located 5' or 3' to the atonal-coding sequences. During chordotonal organ development, the 3' enhancer directs expression in proneural clusters; whereas successive modular enhancers located in the 5' region drive ...

متن کامل

Role of the proneural gene, atonal, in formation of Drosophila chordotonal organs and photoreceptors.

The Drosophila gene atonal encodes a basic helix-loop-helix protein similar to those encoded by the proneural genes of the achaete-scute complex (AS-C). The AS-C are required in the Drosophila PNS for the selection of neural precursors of external sense organs. We have isolated mutants of atonal, which reveal that this gene encodes the proneural gene for chordotonal organs and photoreceptors. I...

متن کامل

The specificity of proneural genes in determining Drosophila sense organ identity

The proneural genes (atonal and the genes of the achaete-scute complex (AS-C)) are required for the selection of sense organ precursors. They also endow these precursors with sense organ subtype information. In most of the ectoderm, atonal is required for precursors of chordotonal sense organs, whereas AS-C are required for those of most external sense organs, such as bristles. To address the q...

متن کامل

Requirement for EGF receptor signalling in neural recruitment during formation of Drosophila chordotonal sense organ clusters

BACKGROUND Drosophila proneural genes act in the process of selecting neural precursors from undifferentiated ectoderm. The proneural gene atonal is required for the development of precursors of both chordotonal organs (stretch receptors) and photoreceptors. Although these types of sensory element are dissimilar in structure and function, they both occur as organized arrays of neurons. Previous...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Mechanisms of Development

دوره 126  شماره 

صفحات  -

تاریخ انتشار 2009